原料药与母体药物

Ezetimibe

CAS 163222-33-1 · C24H21F2NO3 · 61 杂质与相关化合物

01原料药与母体药物

二维结构: Ezetimibe, CAS 163222-33-1 — 结构 Ezetimibe (CAS 163222-33-1). LazyChem 记录. 来源标识: PubChem CID 150311. 分析使用前请核对标识符。下载结构图

CAS RN	163222-33-1
PubChem CID	150311
分子式	C24H21F2NO3
IUPAC 名称	(3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one
已定义立体中心	3
未指定立体中心	0

02亚硝胺结构筛查

记录级结果未发布候选物

该结果不能证明形成风险或不存在风险。需要针对具体工艺进行评估。

03印度监管状态

仅将精确化合物与公布的标识符进行比较。作出监管决定前请核对现行官方文件。

04杂质与相关化合物

(+)-4-Phenyl-2-oxazolidinone

99395-88-7

(2R,3R,6S)-6-(4-Fluorophenyl)tetrahydro-2-(4-hydroxyphenyl)-2H-pyran-3-carboxylic Acid

1618657-31-0

(4S)-3-[(5S)-5-(2-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one

2512202-06-9

(R)-3-((R)-5-(4-fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one

1612153-32-8

(S)-3-((R)-5-(4-Fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one

528565-93-7

(S)-3-((S)-5-Hydroxy-5-phenylpentanoyl)-4-phenyloxazolidin-2-one

2280081-69-6

3-((2S,3R)-2-(4-(Benzyloxy)phenyl)-1-(4-fluorophenyl)-4-oxoazetidin-3-yl)propanoic Acid

204589-82-2

4-((2R,3S,6S)-6-(4-Fluorophenyl)-3-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)phenol

2742940-92-5

4-(4-Fluorobenzoyl)butyric Acid

149437-76-3

4-Fluoroaniline

371-40-4

4'-O-Benzyloxy (3S,4S)-Ezetimibe

1683564-73-9

4CWW589Z2V

1809031-15-9

5-(2-Fluorophenyl)-5-oxovaleric Acid

199664-70-5

Desilylated EZM-II

1621715-63-6

Ent-Ezetimibe Ketone

1376615-01-8

Ezetimibe (RRR)-Isomer / Ezetimibe (3R,4R,3'R)-Isomer

1593542-96-1

Ezetimibe (RSR)-Isomer

1376614-99-1

Ezetimibe (RSS)-Isomer

1478664-18-4

Ezetimibe (SRR)-Isomer / (3’S,3R,4R)-Ezetimibe

1478664-02-6

Ezetimibe (SSR)-Isomer / (3'S, 3S, 4R)-Ezetimibe / (3S, 4R, 3'S)-Ezetimibe

1593543-00-0

Ezetimibe (SSS)-Isomer

1593543-07-7

Ezetimibe 3-Dehydroxy impurity

204589-58-2

Ezetimibe Anhydro impurity- / 3’-Anhydro Ezetimibe

204589-68-4

Ezetimibe Azetidinone Ring-opened Impurity / Ezetimibe Open-Ring Acid

1391053-63-6

Ezetimibe Benzyl Ether Impurity / 4’-O-Benzyloxy Ezetimibe

163222-32-0

Ezetimibe Benzyl Impurity

851860-29-2

Ezetimibe CRS (1269028)

163222-33-1

Ezetimibe Cyclic Ether Impurity / Ezetimibe Tetrahydropyran Analog

1050631-82-7

Ezetimibe cyclized Impurity / Ezetimibe Cyclic Ether Impurity / Ezetimibe Tetrahydropyran Analog

1296129-15-1

Ezetimibe D4 Phenoxy Glucuronide

1426174-41-5

Ezetimibe Deprotected Impurity

1185883-40-2

Ezetimibe Des-alcohol Impurity

RZTACOLCIOSOOX-XZOQPEGZSA-N

Ezetimibe Des-Fluoroaniline Analog

302781-98-2

Ezetimibe Desfluoro Chloro Impurity

1700622-08-7

Ezetimibe Desfluoro Impurity A / Ezetimibe Desfluoro benzene Analog

190595-66-5

Ezetimibe Desfluoro Methyl Impurity

1700622-07-6

Ezetimibe Diacid Impurity

1013025-04-1

Ezetimibe Diol Impurity / Ezetimibe Open-Ring Alcohol

1374250-08-4

Ezetimibe Fluoro Isomer

2743547-96-6

Ezetimibe Hydroxy tert-Butyldiphenylsilyl Ether

1217748-67-8

Ezetimibe Hydroxy β-D-Glucuronide

536709-33-8

Ezetimibe Impurity 11

1607018-83-6

Ezetimibe Impurity 54

1185883-39-9

Ezetimibe Impurity 82

1416263-36-9

Ezetimibe Impurity A

189028-95-3

Ezetimibe Impurity D

272778-12-8

Ezetimibe Ketone Impurity

191330-56-0

Ezetimibe M-Fluoroaniline Analog

1700622-06-5

Ezetimibe O-Fluoroaniline Analog / 2-Azetidinone

2191318-99-5

Ezetimibe Open-Ring Amide Impurity

1197811-72-5

Ezetimibe Other Isomer / Ezetimibe R-Isomer

163380-16-3

Ezetimibe Phenoxy Glucuronide

190448-57-8

Keto Benzylated Ezetimibe

190595-65-4

Methyl 3-((2S,3R)-2-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-4-oxoazetidin-3-yl)propanoate

204589-80-0

Methyl 5-(4-fluorophenyl)-5-hydroxypentanoate

1368310-60-4

N-((1S,2R,5S)-1-(4-(benzyloxy)phenyl)-5-(4-fluorophenyl)-5-hydroxy-2-((S)-2-oxo-4-phenyloxazolidine-3-carbonyl)pentyl)-N-(4-fluorophenyl)nitrous amide

TVDBDGNFJJPTNG-UXWDSZNOSA-N

N-(4-fluorophenyl)-N-((1S,2R,5S)-5-(4-fluorophenyl)-5-hydroxy-2-(hydroxymethyl)-1-(4-hydroxyphenyl)pentyl)nitrous amide

NMGUVIMUHFIQFZ-GKVQRAMASA-N

N-Nitroso Ezetimibe Azetidinone Ring Opened Impurity

KBBKVOZKIRVHMA-ATTQYFOMSA-N

N-Nitroso Ezetimibe Impurity 2

KEBYZTCQHNHNHP-APBNVXTGSA-N

O-Fluoro oxazolidone

2514695-40-8

Rey5S9ZV58

1478663-99-8

05来源

S01
PubChem CID 150311