原料药与母体药物
Venetoclax
CAS 1257044-40-8 · C45H50ClN7O7S · 23 杂质与相关化合物
01原料药与母体药物
| CAS RN | 1257044-40-8 |
|---|---|
| PubChem CID | 49846579 |
| 分子式 | C45H50ClN7O7S |
| IUPAC 名称 | 4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[3-nitro-4-(oxan-4-ylmethylamino)phenyl]sulfonyl-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide |
| 已定义立体中心 | 0 |
| 未指定立体中心 | 0 |
02亚硝胺结构筛查
该结果不能证明形成风险或不存在风险。需要针对具体工艺进行评估。
03印度监管状态
仅将精确化合物与公布的标识符进行比较。作出监管决定前请核对现行官方文件。
04杂质与相关化合物
![二维结构: 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid](/structures/pubchem/66713100/no-cas-2-1h-pyrrolo-2-3-b-pyridin-5-yl-oxy-4-4-4-chloro-5-5-dimethyl-3-4-5-6-tetrahydro-1-1-biphe-2d-structure-300.png)
3-nitro-4-(nitroso((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide
ATQZCJGYOARSMN-UHFFFAOYSA-N
![二维结构: 4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-2-((1-nitroso-1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)benzoic acid](/structures/pubchem/176486915/no-cas-4-4-4-chloro-5-5-dimethyl-3-4-5-6-tetrahydro-1-1-biphenyl-2-yl-methyl-piperazin-1-yl-2-1-n-2d-structure-300.png)
4-aminomethyltetrahydropyran
130290-79-8
![二维结构: Bis(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)methane](/structures/pubchem/177807249/no-cas-bis-4-4-chloro-5-5-dimethyl-3-4-5-6-tetrahydro-1-1-biphenyl-2-yl-methyl-piperazin-1-yl-met-2d-structure-300.png)
Bis(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)methane
HMSGGSSDQCGRKC-UHFFFAOYSA-N
Deschloro Venetoclax Impurity
2573767-91-4
![二维结构: Methyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoate, CAS 1235865-76-5](/structures/pubchem/66713260/1235865-76-5-methyl-2-1h-pyrrolo-2-3-b-pyridin-5-yl-oxy-4-4-4-chloro-5-5-dimethyl-3-4-5-6-tetrahydro-1--2d-structure-300.png)
N-Nitroso Venetoclax DNA Impurity
IZHIXGNENTUPPO-UHFFFAOYSA-N
N-Nitroso Venetoclax Impurity 4
JZEZXIVGFGDTSH-UHFFFAOYSA-N
N-Nitroso Venetoclax Impurity I
QDJDFZCDCLZPRG-UHFFFAOYSA-N
N-Nitroso Venetoclax PNA Impurity
GPIHHUJSLZVKPF-UHFFFAOYSA-N
Venetoclax Cyclic Amide Impurity
UGZMCNZODHUYQE-UHFFFAOYSA-N
Venetoclax Dimer 2 Impurity
2412506-53-5
Venetoclax Dimer Impurity
2270190-88-8
Venetoclax Hydroxy Impurity
2573767-96-9
Venetoclax Impurity 1
FGJTYTQNVPCSHV-UHFFFAOYSA-N
Venetoclax Impurity 2
USUSTBKGHVIJRV-UHFFFAOYSA-N
Venetoclax Impurity 3
KZLLNYWDBBSWNQ-UHFFFAOYSA-N
Venetoclax Impurity G
2573767-90-3
Venetoclax N-Hydroxy Acid Impurity
2514648-06-5
Venetoclax N-Oxide Impurity
2469279-00-1
Venetoclax Positional Isomer
CMEGDEFIXRDDON-UHFFFAOYSA-N
05来源
- S01