原薬と親化合物

Tofacitinib Citrate

CAS 540737-29-9 · C22H28N6O8 · 46 不純物と関連化合物

01原薬と親化合物

2D 構造: Tofacitinib Citrate, CAS 540737-29-9 — 構造 Tofacitinib Citrate (CAS 540737-29-9). LazyChem レコード. 出典識別: PubChem CID 10174505. 分析に使用する前に識別子を確認してください。構造画像をダウンロード

CAS RN	540737-29-9
PubChem CID	10174505
分子式	C22H28N6O8
IUPAC 名	(3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-1-piperidinepropanenitrile; 2-Hydroxy-1,2,3-propanetricarboxylate
定義済み立体中心	2
未指定立体中心	0

02ニトロソアミン構造スクリーニング

記録単位の結果候補は公開されていません

この結果は生成またはリスク不在を証明しません。工程固有の評価が必要です。

03インドでの規制状況

公開識別子との比較は正確な化合物のみを対象とします。規制判断の前に現行の公式文書を確認してください。

04不純物と関連化合物

(3R,4R)-1-Nitroso Tofacitinib

TXSGUQKMDXUZIR-KOLCDFICSA-N

(3R,4R)-N,4-Dimethyl-1-benzyl-3-piperidinamine

477600-70-7

(3S,4S)-Tofacitinib

1092578-47-6

1,8-Diazabicyclo[5.4.0]undec-7-ene

6674-22-2

2-chloro-N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

1616760-97-4

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine

90213-66-4

3-((3R,4R)-4-Methyl-3-(methyl(5-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile

2101951-20-4

3-(4-methyl-3-(methyl(7-nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile

AQKUOYKGUYJXMS-UHFFFAOYSA-N

4-chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

16372-08-0

4'-Chloro-4,7'-bi-7H-pyrrolo[2,3-d]pyrimidine

134965-85-8

5,7-dihydro-6H-pyrrolo [2,3-d] pyrimidin-6-one impurity

5817-96-9

6-Chloro-7-Deazapurine

3680-69-1

7-Tosyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one

2250241-69-9

C27H31N5O2S

923036-30-0

CP-690550 N-Hydroxyl

2407039-29-4

Dihydro Tofacitinib Impurity / 5,6-Dihydro Tofacitinib

1640972-35-5

Ethyl 4-cyano-3-imino-5-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-5-oxopentanoate

2102039-99-4

EXA92262Y4

2227199-31-5

N-((3R,4R)-1-(2-cyanoacetyl)-4-methylpiperidin-3-yl)-N-methylnitrous amide

NISOYRYSXJKHEN-BDAKNGLRSA-N

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylnitrous amide

HRTOTRFZITXVML-OCCSQVGLSA-N

N-Desmethyl Tofacitinib

1527525-58-1

N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-amine

1812890-23-5

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)nitrous amide

UDRIDHRXFSNEMK-RQJHMYQMSA-N

N-methyl-N-((3S,4S)-4-methyl-1-nitrosopiperidin-3-yl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-amine

PLJTXDHJSKQHPP-GXSJLCMTSA-N

N-methyl-N-((3S,4S)-4-methyl-1-nitrosopiperidin-3-yl)-7-nitroso-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-amine

AOZKVNAXBBJZNA-GXSJLCMTSA-N

N-methyl-N-((3S,4S)-4-methyl-1-nitrosopiperidin-3-yl)-7-nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-amine

CAKBVPHVKKJQGG-GXSJLCMTSA-N

N-methyl-N-(3R,4R)-(4-methyl-1-nitrosopiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

PMIKZRGUWPYFRP-KOLCDFICSA-N

N-methyl-N-(4-methyl-1-nitrosopiperidin-3-yl)nitrous amide

FLHWBBFXKFOMJT-UHFFFAOYSA-N

N-Methyl-N-Nitroso-o-toulidine / N-nitroso-N-methyltoluidine

10596-01-7

N-Nitroso 5,6-Dihydro Tofacitinib

PDKNPOLZHRCWSZ-YPMHNXCESA-N

N-Nitroso Tofacitinib

AQKUOYKGUYJXMS-YPMHNXCESA-N

N-Nitroso Tofacitinib Impurity 2

NKAOYNFDWWKGJY-JTDNENJMSA-N

Tofacitinib (3R,4S)-Isomer

1092578-46-5

Tofacitinib (3S,4R)-Isomer

1092578-48-7

Tofacitinib Acid Impurity / Tofacitinib Inhouse Impurity K

2328165-36-0

Tofacitinib Amide Impurity

1675248-19-7

Tofacitinib Benzyl Impurity / Des-(N-oxopropanenitrile)-N-methylbenzyl

477600-73-0

Tofacitinib Citrate Diastereomer Impurity (3RS, 4SR Isomer)

SYIKUFDOYJFGBQ-UHFFFAOYSA-N

Tofacitinib Diastereomer-1 and 2

2734856-31-4

Tofacitinib Impurity TOF-IV

2227197-38-6

Tofacitinib Impurity V

1616761-00-2

Tofacitinib metabolite-1

1640971-51-2

Tofacitinib N-Descyanoacetyl Impurity

477600-74-1

Tofacitinib N-Hydroxy Impurity

2459302-76-0

Tofacitinib N-oxide impurity

2028267-73-2

Tofacitinib R,S Isomers

1638499-31-6

05情報源

S01
PubChem CID 10174505