API e farmaco progenitore
Simvastatin
CAS 79902-63-9 · C25H38O5 · 65 Impurezze e composti correlati
01API e farmaco progenitore

| CAS RN | 79902-63-9 |
|---|---|
| PubChem CID | 54454 |
| Molecular formula | C25H38O5 |
| IUPAC name | [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate |
| Defined stereocentres | 7 |
| Unassigned stereocentres | 0 |
02Screening strutturale delle nitrosammine
Structure-only screen. Manufacturing conditions, nitrite sources, pH, temperature and purge controls require a separate process assessment.
03Stato in India
Exact-compound comparison only. Confirm the current official instrument before making a regulatory decision.
04Impurezze e composti correlati
![Two-dimensional chemical structure of (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R)-tetrahydro-4,6-dioxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl 2,2-Dimethylbutanoate, CAS 1426939-44-7](/structures/pubchem/163490143-300.png)
![Two-dimensional chemical structure of (1S,6S,7R,8S,8aR)-6-Hydroxy-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate, CAS 133645-46-2](/structures/pubchem/21728613-300.png)
![Two-dimensional chemical structure of [(1R,3R,4S,7S,8S)-4-hydroxy-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,4,7,8-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate](/structures/pubchem/163203369-300.png)
![Two-dimensional chemical structure of [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-tetrahydropyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate; [(1R)-2-(6-aminopurin-9-yl)-1-methyl-ethoxy]methylphosphonic acid](/structures/pubchem/49777163-300.png)
![Two-dimensional chemical structure of [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-tetrahydropyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate; 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylene-cyclopentyl]-1H-purin-6-one](/structures/pubchem/136195473-300.png)
![Two-dimensional chemical structure of [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-tetrahydropyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate; 4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one](/structures/pubchem/49777165-300.png)
![Two-dimensional chemical structure of [(1S,3R,7S,8S)-8-[2-[(2R,4R)-4-hydroxy-5-methyl-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate](/structures/pubchem/163203368-300.png)
![Two-dimensional chemical structure of [(1S,6S,7R,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-6-methoxy-3,7-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate](/structures/pubchem/163203372-300.png)

2,3-Dehydro Simvastatin Acid (Sodium Salt)
393825-04-2

2'-Ethyl Simvastatin-D6
KJXWSYMXRPCCCZ-XLKJLTKWSA-N

3-Hydroxy Simvastatin
134523-09-4

3-Methylene Simvastatin Impurity
79902-62-8


3',5'-Dihydrodiol Simvastatin
159143-77-8


3',5'-Dihydrodiol Simvastatin-d6
MRCKOKWQDZYFLT-QCUYXPMWSA-N

3"-Hydroxy Simvastatin Acid (Sodium Salt)
1316302-95-0

3(R)-Hydroperoxy Simvastatin
1092716-42-1



4,5-Dihydro Simvastatin-D6
JJGRUACCESEJJW-KNJXVUBNSA-N


5'-Chloro-6'-Oxo Simvastatin
134395-21-4

6-Exomethylenesimvastatin
121624-18-8

6-Oxo Simvastatin
NPDFVGFXQSJBAA-HJSUOQFFSA-N

6-Oxo Simvastatin-D6
NPDFVGFXQSJBAA-BVIAEFNZSA-N

6'-Carboxy Simvastatin
114883-30-6

6’-Carboxy Simvastatin-D6
1346604-34-9

6'-Exomethylene Simvastatin Acid (Sodium Salt)
WWMPCNNKBVKGMO-GVVNIZFTSA-M


6(S)-Hydroperoxy Simvastatin
149949-01-9



Hydroxymethyl Simvastatin
FPUXRLQQFNQSBI-XEWBTUSXSA-N

N-Desmethyl Rosuvastatin-D3
DJUKMHIJCDJSIJ-SASHQDCGSA-N
![Two-dimensional chemical structure of prop-2-enyl (2S,3S,4S,5R,6S)-6-[(3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoyl]oxy-3,4,5-trihydroxyoxane-2-carboxylate](/structures/pubchem/169446401-300.png)
![Two-dimensional chemical structure of prop-2-enyl (2S,3S,4S,5R)-6-[(E,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-5-prop-2-enoxycarbonyloxyhept-2-enoyl]oxy-3,4,5-trihydroxyoxane-2-carboxylate](/structures/pubchem/163285481-300.png)

Simvastatin Acid Ammonium Salt Impurity
139893-43-9

Simvastatin Acid-D3
PLNPEDNGLSMHOD-MFIUAOMZSA-N

Simvastatin acyl-b-D-glucuronide
463962-56-3

Simvastatin Carboxylic Acid 2,2-Dimethyl-3-hydroxy Ester
QRIIRXKWFWSGEB-SSFSUTQVSA-N











Simvastatin Impurity 8
NPDFVGFXQSJBAA-ZBDDBYLNSA-N

Simvastatin Impurity 16
GTXCWVZVLSZOGK-ZNFHGHDDSA-N

Simvastatin Impurity 17
SUKGPYIDIDAMAR-UTFAGHIVSA-N

Simvastatin Impurity 18
MZPLCUOGFMLLBZ-VXEVXMTNSA-N

Simvastatin Impurity 19
NDJRQKHMWWVASB-ZIIGMLFBSA-N

Simvastatin Impurity 21
WILKRHSPZPHHIZ-MEXSBJDLSA-N

Simvastatin Impurity 22
HOWILKPGWHOYSY-YKAZEBNLSA-N

Simvastatin Impurity 27
132487-01-5

Simvastatin Impurity 29
TVXUFXKGEHQFFN-XEUIXTRBSA-N

Simvastatin-D3
RYMZZMVNJRMUDD-LONBHWHVSA-N

Simvastatin-D11
1002347-74-1

Simvastatin, 1-Pyreneacetyl Ester
193682-18-7
![Two-dimensional chemical structure of sodium (3R)-7-[(1S,2S,6R,8S)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate](/structures/pubchem/168315234-300.png)
![Two-dimensional chemical structure of sodium;(3R)-7-[(1S,2S,6R,8S)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate;hydride](/structures/pubchem/132989006-300.png)
05Fonti
- S01
