Chemical identity

Chlortetracycline EP Impurity E/ Demeclocycline EP Impurity B/ 4-Epi Demeclocycline/ 4-Epi Demethyl Chlortetracycline

CAS 14206-59-8 · C21H21ClN2O8

01Identity

Identifiers and names for this exact compound. Empty fields are left unassigned.

Lazychem IDLC-10547
PubChem CID54731359
NameChlortetracycline EP Impurity E/ Demeclocycline EP Impurity B/ 4-Epi Demeclocycline/ 4-Epi Demethyl Chlortetracycline
CAS RN14206-59-8
Molecular formulaC21H21ClN2O8
Molecular weight464.85 g/mol
IUPAC name(4R,4aS,5aS,6S,12aS)-7-Chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
InChIKeyGUXHBMASAHGULD-PTACOPLGSA-N

02Structure identifiers

2D structurePubChem CID 54731359
Two-dimensional chemical structure of Chlortetracycline EP Impurity E/ Demeclocycline EP Impurity B/ 4-Epi Demeclocycline/ 4-Epi Demethyl Chlortetracycline, CAS 14206-59-8
Two-dimensional structure for the PubChem identity linked to this record. Confirm the identifiers before analytical use.

The parsed structure contains 4 rings, includes aromatic atoms, includes aliphatic carbon, has 5 defined stereocentres, contains at least one halogen atom. These statements are calculated from the published structure string.

Defined stereocentres5
Unassigned stereocentres0
Ring count4
Secondary amines0
Tertiary amines1
N-methyl amine sites2
SMILESCN(C)[C@@H]1[C@@H]2C[C@@H]3[C@@H](C4=C(C=CC(=C4C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O)Cl)O
InChINot listed
Formula from structureC21H21ClN2O8
Molecular weight from structure464.85 g/mol

03Stereochemistry

The published structure contains 5 defined and 0 unassigned tetrahedral stereocentres. The exact wedge and dash depiction is shown above.

Defined centres5Structure assigned
Unassigned centres0Structure unspecified
Assignment statusFully assignedExact published identity
Tetrahedral upper bound≤ 32Before symmetry reduction

Published same-connectivity configurations

3 records

These records have the same connectivity, molecular formula and protonation layer, but a different complete InChIKey stereochemical layer. Only separately structure-linked records are shown.

Scope: The mathematical 2^n value is only an upper bound. Symmetry and other stereogenic elements can change the number of distinct stereoisomers. A hypothetical configuration is not published as a compound record without a verified structure identity.

04Possible N-nitroso structures

Shown for structural screening only. These candidates are not confirmed impurities, formation predictions or analytical findings.

Matched amine site1 candidate
Chemical structure of Chlortetracycline EP Impurity E/ Demeclocycline EP Impurity B/ 4-Epi Demeclocycline/ 4-Epi Demethyl Chlortetracycline with the matched amine site highlighted in amber
Amber identifies the screened atom and adjacent bonds.
Possible structure candidateUnverified identity
First calculated possible N-nitroso structure derived from Chlortetracycline EP Impurity E/ Demeclocycline EP Impurity B/ 4-Epi Demeclocycline/ 4-Epi Demethyl Chlortetracycline, with the new N-nitroso group highlighted in amber
The new N-N=O atoms and bonds are highlighted. No CAS number or compound name is assigned by this calculation.
Candidate 1Possible N-nitroso structural candidate
Calculated formula
C20H18ClN3O9
Candidate SMILES
CN(N=O)[C@H]1C(=O)C(C(N)=O)=C(O)[C@@]2(O)C(=O)C3=C(O)c4c(O)ccc(Cl)c4[C@@H](O)[C@H]3C[C@@H]12

Interpretation: A structural alert alone does not establish that a nitrosamine forms. Evaluate nitrite sources, amine reagents, pH, temperature, process sequence, purge and analytical evidence.

05India status for this compound

These results apply only to this exact compound name and CAS number. Confirm the current official instruments before making a regulatory decision.

NDPS / RCSNO EXACT MATCH FOUNDCAS 14206-59-8 has no exact match in the reviewed published schedule.
SCOMETNO EXACT REVIEWED CAS MATCHCAS 14206-59-8 has no exact match in the reviewed SCOMET list.
Review date2026-08-01Recheck the current official instruments for the material, concentration, activity and date in question.

06Names and relationships

Associated parent compound

Chlortetracycline; Demeclocycline

View API and impurity family

Other names

  • Chlortetracycline EP Impurity E
  • Demeclocycline EP Impurity B / 4-Epi Demeclocycline / 4-Epi Demethyl Chlortetracycline
  • 4-Epidemethylchlortetracycline
  • 4-Epidemeclocycline
  • 14206-59-8
  • 4-epi-Demeclocycline (~90%)
  • (4R,4aS,5aS,6S,12aS)-7-Chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
  • YF293A4IUH
  • (4R,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide
  • 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, (4R,4aS,5aS,6S,12aS)-
  • 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, 4-epimer
  • UNII-YF293A4IUH

Related records from the same parent family

07Documented history

Dated discovery, occurrence, use and issue claims are published only when a suitable primary or government source is available.

No dated history available

No verified discovery, first report, occurrence, use or issue event is currently available for this identity.

08Sources